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Tretinoin cream side effects are common, especially when starting this powerful skincare treatment. Used to treat acne, wrinkles, and dark spots, tretinoin can cause temporary skin irritation as your skin adjusts. The most reported tretinoin cream side effects include dryness, redness, peeling, and a burning or stinging sensation. Some users also experience a “purging” phase, where breakouts may worsen before they improve. These effects typically lessen over time as your skin builds tolerance. To manage tretinoin cream side effects, start with a lower strength, apply it only at night, and use a gentle moisturizer and sunscreen daily. Avoid exfoliants and other harsh products during the adjustment period. If you experience severe side effects like swelling or blistering, stop using the cream and consult a dermatologist. Being informed about tretinoin cream side effects helps you stay consistent with treatment and achieve clearer, healthier skin with minimal discomfort over time.