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Clindamycin is a widely used antibiotic that helps treat various bacterial infections, including skin infections, acne, dental infections, and respiratory conditions. While it’s generally effective and well-tolerated, like any medication, it can cause side effects in some people. The most common side effects of clindamycin include stomach discomfort, nausea, vomiting, and diarrhea. These symptoms are usually mild and may improve as your body adjusts to the medication. If you're using topical clindamycin for acne, you might notice dryness, itchiness, or redness on your skin—especially during the first few weeks of use. One important thing to be aware of is the risk of Clostridium difficile-associated diarrhea (CDAD), a more serious condition that can occur when clindamycin disrupts the balance of healthy bacteria in your gut. This can lead to severe, persistent diarrhea and abdominal pain. If this happens, it’s important to stop the medication and seek medical help immediately. In rare cases, some people may experience allergic reactions, such as rash, itching, or swelling, especially of the face, tongue, or throat. Difficulty breathing is a medical emergency and requires immediate attention. To reduce the risk of side effects, always follow your doctor’s instructions carefully and avoid using clindamycin longer than prescribed. Drinking plenty of water and maintaining a balanced diet can also help support your gut during treatment. Understanding the possible clindamycin side effects helps you use the medication more safely and confidently. Always listen to your body—if something feels off, don’t hesitate to reach out to your healthcare provider.